Can I take antihistamines everyday? More than the recommended dose? What if I’m pregnant? Here’s what the research says

Source: The Conversation (Au and NZ) – By Janet Davies, Respiratory Allergy Stream Co-chair, National Allergy Centre of Excellence; Professor and Head, Allergy Research Group, Queensland University of Technology

Allergies happen when your immune system overreacts to a normally harmless substance like dust or pollen. Hay fever, hives and anaphylaxis are all types of allergic reactions.

Many of those affected reach quickly for antihistamines to treat mild to moderate allergies (though adrenaline, not antihistamines, should always be used to treat anaphylaxis).

If you’re using oral antihistamines very often, you might have wondered if it’s OK to keep relying on antihistamines to control symptoms of allergies. The good news is there’s no research evidence to suggest regular, long-term use of modern antihistamines is a problem.

But while they’re good at targeting the early symptoms of a mild to moderate allergic reaction (sneezing, for example), oral antihistamines aren’t as effective as steroid nose sprays for managing hay fever. This is because nasal steroid sprays target the underlying inflammation of hay fever, not just the symptoms.

Here are the top six antihistamines myths – busted.

Myth 1. Oral antihistamines are the best way to control hay fever symptoms

Wrong. In fact, the recommended first line medical treatment for most patients with moderate to severe hay fever is intranasal steroids. This might include steroid nose sprays (ask your doctor or pharmacist if you’d like to know more).

Studies have shown intranasal steroids relieve hay fever symptoms better than antihistamine tablets or syrups.

To be effective, nasal steroids need to be used regularly, and importantly, with the correct technique.

In Australia, you can buy intranasal steroids without a doctor’s script at your pharmacy. They work well to relieve a blocked nose and itchy, watery eyes, as well as improve chronic nasal blockage (however, antihistamine tablets or syrups do not improve chronic nasal blockage).

Some newer nose sprays contain both steroids and antihistamines. These can provide more rapid and comprehensive relief from hay fever symptoms than just oral antihistamines or intranasal steroids alone. But patients need to keep using them regularly for between two and four weeks to yield the maximum effect.

For people with seasonal allergic rhinitis (hayfever), it may be best to start using intranasal steroids a few weeks before the pollen season in your regions hits. Taking an antihistamine tablet as well can help.

Antihistamine eye drops work better than oral antihistamines to relieve acutely itchy eyes (allergic conjunctivitis).

Myth 2. My body will ‘get used to’ antihistamines

Some believe this myth so strongly they may switch antihistamines. But there’s no scientific reason to swap antihistamines if the one you’re using is working for you. Studies show antihistamines continue to work even after six months of sustained use.

Myth 3. Long-term antihistamine use is dangerous

There are two main types of antihistamines – first-generation and second-generation.

First-generation antihistamines, such as chlorphenamine or promethazine, are short-acting. Side effects include drowsiness, dry mouth and blurred vision. You shouldn’t drive or operate machinery if you are taking them, or mix them with alcohol or other medications.

Most doctors no longer recommend first-generation antihistamines. The risks outweigh the benefits.

The newer second-generation antihistamines, such as cetirizine, fexofenadine, or loratadine, have been extensively studied in clinical trials. They are generally non-sedating and have very few side effects. Interactions with other medications appear to be uncommon and they don’t interact badly with alcohol. They are longer acting, so can be taken once a day.

Although rare, some side effects (such as photosensitivity or stomach upset) can happen. At higher doses, cetirizine can make some people feel drowsy. However, research conducted over a period of six months showed taking second-generation antihistamines is safe and effective. Talk to your doctor or pharmacist if you’re concerned.

Myth 4. Antihistamines aren’t safe for children or pregnant people

As long as it’s the second-generation antihistamine, it’s fine. You can buy child versions of second-generation antihistamines as syrups for kids under 12.

Though still used, some studies have shown certain first-generation antihistamines can impair childrens’ ability to learn and retain information.

Studies on second-generation antihistamines for children have found them to be safer and better than the first-generation drugs. They may even improve academic performance (perhaps by allowing kids who would otherwise be distracted by their allergy symptoms to focus). There’s no good evidence they stop working in children, even after long-term use.

For all these reasons, doctors say it’s better for children to use second-generation than first-generation antihistimines.

What about using antihistimines while you’re pregnant? One meta analysis of combined study data including over 200,000 women found no increase in fetal abnormalities.

Many doctors recommend the second-generation antihistamines loratadine or cetirizine for pregnant people. They have not been associated with any adverse pregnancy outcomes. Both can be used during breastfeeding, too.

Myth 5. It is unsafe to use higher than the recommended dose of antihistamines

Higher than standard doses of antihistamines can be safely used over extended periods of time for adults, if required.

But speak to your doctor first. These higher doses are generally recommended for a skin condition called chronic urticaria (a kind of chronic hives).

Myth 6. You can use antihistamines instead of adrenaline for anaphylaxis

No. Adrenaline (delivered via an epipen, for example) is always the first choice. Antihistamines don’t work fast enough, nor address all the problems caused by anaphylaxis.

Antihistamines may be used later on to calm any hives and itching, once the very serious and acute phase of anaphylaxis has been resolved.

In general, oral antihistamines are not the best treatment to control hay fever – you’re better off with steroid nose sprays. That said, second-generation oral antihistamines can be used to treat mild to moderate allergy symptoms safely on a regular basis over the long term.

Janet Davies receives funding from the ARC, NHMRC, Department of Health and Aging, and MRFF. She has conducted research on diagnostics in collaboration with Abionic SA, Switzerland, supported by the National Foundation for Medical Research Innovation with co-contribution from Abionic. Her allergy research has been supported by in kind services or materials from Sullivan Nicolaides Pathology (Queensland), Abacus Dx (Australia), Stallergenes (France), Stallergenes Greer (Australia), Swisens (Switzerland), Kenelec (Australia), and ThermoFisher (Sweden), as well as cash or in kind contributions from Partner Organisations for the NHMRC AusPollen Partnership Project GNT1116107, Australasian Society Clinical Immunology Allergy, Asthma Australia; Stallergenes Australia; Bureau Meteorology, Commonwealth Scientific Industrial Research Organisation, Federal Office of Climate and Meteorology Switzerland. QUT owns patents relevant to grass pollen allergy diagnosis (US PTO 14/311944 issued, AU2008/316301 issued) for which Janet Davies is an inventor. She is the Executive Lead, Repository and Discovery Pillar, and Co-Chair Respiratory Allergy Stream for the National Allergy Centre of Excellence.

Connie Katelaris has received funding from the NHMRC for aerobiological research. Unrelated to this article, she has been a consultant on advisory boards or has received honoraria for presentations from Takeda, CSL Behring, GSK, Sanofi, Phavaris, Biocryst, KalVista, Astra Zeneca, Stallergenes, Novartis. She has had an unrestricted research grant from CSL Behring. None of the presentations for these companies was on any topic related to this article and did not involve discussions on intranasal steroid sprays or antihistamines.

Unrelated to this article, Joy Lee has received funding from the Centre of Research Excellence in Treatable traits in Asthma, Sanofi, Fondazione Menarini and GSK. This funding support was solely used for presenting at educational meetings in asthma and travel grants to attend international meetings and conferences in Asthma. She has been on advisory boards for Tezepelumab (Astra Zeneca). She is affiliated with the National Allergy Centre of Excellence as the co-chair of the Respiratory Allergy Leadership Group. A/Prof Lee declares she has not received any funding directly from any of the above pharmaceutical companies directly related to the selling, education or patient use of antihistamines or intranasal steroids. In this article we discuss antihistamines and intranasal steroids generically as classes of medications and do not specifically advocate for one particular brand over another.

– ref. Can I take antihistamines everyday? More than the recommended dose? What if I’m pregnant? Here’s what the research says – https://theconversation.com/can-i-take-antihistamines-everyday-more-than-the-recommended-dose-what-if-im-pregnant-heres-what-the-research-says-228390